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UCI Lung Center
University of California, Irvine
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 Matthew Brenner, MD
Professor of Medicine
Chief, Pulmonary and Critical Care Medicine
Dr. Brenner came to UCI in 1987 from after a fellowship in critical care medicine at the National Institutes of Health. He completed a fellowhip in pulmonary medicine at UCI, and joined the full time faculty in 1988. Previously, Brenner had trained at UC San Diego in internal medicine. Dr. Brenner's major focus has been in understanding surgical approaches to treatment of emphysema. More recently, his work has been directed toward development of new laser diagnostic technologies for translation to clinical pulmonary and critical care medicine. He works with the laser engineering research group at the Beckman Laser Institute on the main UC Irvine Campus developing high resolution flexible fiberoptic optical coherence tomography technology for airways and frequency domain photon migration diagnostics for assessment of hemodynamic alterations.
Dr. Brenner has authored over 80 peer-reviewed original research articles, in addition to numerous book chapters, review papers, and critical care manuals. Dr. Brenner has served as a reviewer for a number of journals, grant review committies (including ALAC, and NIH) and as chair of an NIH SBIR study section. Dr. Brenner is a well recognized leader in the field of understanding lung volume reduction surgical (LVRS) procedures. He lectures throughout the United States on new approaches to LVRS, and more recently on his current research in innovative laser optical pulmonary diagnostic technology development.
Dr. Brenner, like the other faculty in the pulmonary division at UC Irvine, maintains a strong interest in clinical medicine and teaching, with regular attendance on pulmonary consultative services, clinics, and the ICU.
Selected publications:
- Brenner M, Shankel T, Waite T, Hamilton A, Wang N, Roeck W, Tadir Y, Milner T, Tromberg B, Wilson AF, Berns MW. An animal model for thoracoscopic laser ablation of emphysematous pulmonary bullae. Lasers in Surgery and Medicine, 18:191-196, 1996.
- McKenna RJ, Jr, Brenner M, Mullin M, Singh N, Peters H, Panzera J, Calmese J. A randomized prospective trial of stapled lung reduction versus laser bullectomy for diffuse emphysema. J Thoracic and Cardiovasc Surg, 111(2):317-21, 1996.
- Brenner M, Yusen R, McKenna RJ, Sciurba F, Gelb A, Fischel R, Swain J, Chen JC, Kafie F, Lefrak S. Lung volume reduction surgery for emphysema. Chest 110:205-18, 1996.
- Tromberg BJ, Coquoz O, Fishkin JB, Anderson ER, Pham D, Brenner M, Svaasand LO. Frequency-domain photon migrating (FDPM) measurements of normal and malignant cell and tissue optical properties. Optical Society of America TOPS on Biomedical Optical Spectroscopy and diagnostics, Orlando, 3:111-116, 1996.
- Fishkin JB, Coquoz O, Anderson ER, Brenner M, Tromberg BJ. Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject. Applied Optics (special issue). Vol. 36, (1): 10-20, 1997.
- Brenner M, McKenna RJ Jr, Gelb AF, Osann K, Schein MJ, Panzera J, Wong H, Berns MW, Wilson AF. Objective predictors of response for staple versus laser emphysematous lung reduction. Am J Resp Crit Care Med, 155:1295-1301, 1997.
- Brenner M, McKenna RJ, Gelb A, Fischel RJ, Yoong B, Huh J, Osann K, Chen JC. Dyspnea response following bilateral thoracoscopic staple lung volume reduction surgery. Chest. 112:916-23, 1997.
- Huh J, Brenner M, Chen JC, Yoong B, Gassel A, Kafie F, Milliken J, McKenna RJ Jr, Fischel RJ, Gelb AF, Wilson AF. Changes in pulmonary physiology after lung volume reduction surgery in a rabbit model of emphysema. J Thorac Cardiovasc Surg. 115(2):328-35, 1998.
- Brenner M, McKenna RJ Jr, Gelb AF, Fischel RJ, Wilson AF. Rate of FEV1 change following lung volume reduction surgery. Chest, 113(3):652-659, 1998.
- Powell LL, Serna DL, Brenner M, Jalal R, Gaon M, Burney T, Monti-Frayne J, McKenna RJ Jr, Chen JC. Changes in pulmonary physiology after lung volume reduction surgery in rabbits with moderate and severe emphysema. Surgical Forum, 49:266-268, 1998.
- Brenner M, McKenna RJ Jr, Chen JC, Osann K, Powell L, Gelb AF, Fischel RJ, Wilson AF. Survival following bilateral staple lung volume reduction surgery for emphysema. Chest, 115(2):390-396, 1999.
- Brenner M, McKenna RJ, Jr., Chen JC, Serna DL, Powell LL, Gelb AF, Fischel RJ, Wilson AF. Relationship between amount of lung resected and outcome after lung volume reduction surgery. Annals of Thoracic Surgery 69(2):388-93. 2000.
- Gelb, A.F., McKenna RJ, Brenner M. Lung Function 5 yr after Lung Volume Reduction Surgery for Emphysema. Am J Respir Crit Care Med, 2001. 163(7): p. 1562-1566.
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