Sai-Hong Ignatius Ou, MD, PhD, Thoracic Oncologist - UCI Lung Center, Orange, CA - Pulmonologists, Univ. of California, Irvine

UCI Lung Center
University of California, Irvine

Sai-Hong Ignatius Ou, MD, PhD, Thoracic Oncologist Sai-Hong Ignatius Ou, MD, PhD
Assistant Clinical Professor of Medicine
Chao Comprehensive Cancer Center

Background
I graduated from University of Texas Southwestern Medical School in 1997 with both MD and PhD degrees. My PhD research was in the regulation of the HIV-1 gene promoter. I completed my internal medicine residency training at Duke University Medical Center in 2000. I then completed my hematology-medical oncology fellowship training at Beth Israel Deaconess Medical Center in Boston, Massachusetts in 2003. During my fellowship training, I concentrated in clinical research in upper aerodigestive tract malignancies.
Clinical and Research Interests
Nasopharyngeal carcinoma
Head and neck cancer
Thoracic malignancies
Esophageal carcinoma

My interests at UCI will be to incorporate novel and targeted therapies in the treatment of upper aero-digestive tract malignancies. I am particularly interested in nasopharyngeal carcinoma (NPC). NPC is endemic in Southeast Asia with the highest incidence in Southern China. NPC has been closely associated with Epstein-Barr virus (EBV). Thus, EBV provided a potential target in the treatment of NPC which includes both radiation and chemotherapy. Measuring the actual EBV viral load in blood has also been shown to be useful in prognosis if treatment outcome and monitoring treatment of NPC and even surveillance. The radiation oncology group at UCI also has state of the art radiation treatment facilities including Intensity Modulated Radiation Therapy (IMRT) which can better spare normal tissues from radiation. Together with our excellent otolaryngology surgeons and radiation oncologist, we can plan to provide the state of the art treatment for head and neck cancers.
Selected Recent Publications
Lalazar, A., Ou, Sai-Hong Ignatius., and Mahley, R. W. 1989. Human apolipoprotein E: Receptor binding activity of truncated variants with carboxyl-terminal deletions. J. Biol. Chem. 264: 8447-8450.
Matsumine, H., Herbst, M. A., Ou, S.-H. Ignatius., Wilson, J. D., and McPhaul, M. J. 1991. Aromatase mRNA in the extragonadal tissues of chicken with henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. J. Biol. Chem. 266: 19900-19907.
Garcia, J. A., Ou, S.-H. Ignatius*., Wu, F., Lusis, A. L., Sparkes, R. S., and Gaynor, R. B. 1992. Cloning and chromosomal mapping of a human immunodeficiency virus 1 ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂTATAÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂ element modulatory factor. Proc. Natl. Acad. Sci. 89: 9372-9376 (* co-first author).
Ou, S.-H. Ignatius.,Garcia-Martinez, L. F., Paulssen, E. J., and Gaynor, R. B. 1994. Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J. Virol. 68: 7188-7199.
Ou, S.-H. Ignatius., Wu, F., Harrich, D., Garcia-Martinez, L. F., and Gaynor, R. B. 1995. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J. Virol. 69: 3584-3596.
Mavankal, G., Ou, S.-H. Ignatius., Oliver, H., Sigman, D., and Gaynor, R. G. 1996. Human immunodeficiency virus type 1 and 2 Tat proteins specifically interact with RNA polymerase II. Proc. Natl. Acad. Sci. 93: 2089-2094.
Petti, C. A., Ou, S.-H. Ignatius., and Sexton, D. J. 2002. Acute terminal ileitis associated with pneumococcal bacteremia: case report and review of pneumococcal gastrointestinal diseases. Clinical Infectious Diseases 34: e50-e53.
Ou, S.-H. I., Wu, F., and Gaynor, R. B. 1995. Analysis of HIV-1 LTR DNA binding proteins. Pages 211-230. HIV: A practical Approach. Volume 2. Biochemistry, molecular biology and drug discovery. Edited by J. Karn. IRL Press at Oxford University Press.
Ou, S.-H. Ignatius., and Gaynor, Richard B. 1995. Intracellular factors involved in gene expression of human retroviruses. Pages 97-184. The Retroviridae, Volume 4, edited by

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